Bah, though the phrase often is "trying too hard," there is also such a thing as "not trying hard enough" >.> . If they could get a whole clusterfbomb of memes in there, the sheer weirdness of it all could balance out the lackluster parts... but with just a sprinkling of Youtube sensations in there, I don't think the plot will be awesome/interesting enough to support itself :/
My (however damned unlikely) wishlist:
Chadwardenn
Star Wars kid (but then he actually turned down roles in Star Wars ep I or II and is currently joining the Canadian ruling class ._.)
Boxxy
Chuck Norris (of course!)
Vegeta's Ocean voice actor (he's actually done the "over 9000" line at conventions)
Tommy "The Room" Wiseau
Darren "They're eating her... and then they're going to eat me!" Ewing
Eric "GARBAGE DAY!" Freeman
Bruno "Hitler freaks out" Ganz (hey, it'd be good to have at least one "best actor" in the cast!)
Brian "Hello Mr. Kubrick!" Atene
Blood kid
Samuel L. Jackson (reprising his role as Neville Flynn)
Wilford "Diabeetus" Brimley
Gerard "THIS IS SPARTA" Butler
Don "Stingray from Best Fight Scene" Niam
Tourette's guy (provided he didn't really die)
Taye Zonday
SUPER DRAGON! *clap clap clapclapclap*
Kanye "Best video of all time!" West
Charlie Sheen (due to recent events)
And of course, Rick Astley himself